Discover how the Dose Range Finding (DRF) assay and zebrafish as an alternative model are revolutionizing preclinical research. Learn how DRF determines compound tolerability levels and why zebrafish, with their genetic similarity to humans, transparency, and cost-effectiveness, are invaluable in toxicity screening. Find out how...
Researchers from the University of Washington and University Hospital Heidelberg have developed new research advances in the treatment of muscular dystrophy using split intein-mediated protein trans-splicing, that allow for the production of functional dystrophin proteins in vitro and in vivo. Muscular dystrophy is a genetic disorder...
Teratogenicity testing is a crucial step in drug development to identify substances that can cause physical or functional defects in human embryos or fetuses. Following the Thalidomide tragedy in the 1950s and 1960s, it became mandatory to assess a drug's potential to induce congenital defects...
The drug discovery process is a lengthy and expensive endeavor that can take up to a decade or more and cost upwards of $1 billion. In order to develop effective drugs, researchers use preclinical trials to identify specific molecules (Lead Candidates) that possess the necessary...
As researchers in the field of developmental biology and animal modeling, We have discovered the advantages of using zebrafish embryos as an alternative to traditional animal models such as mice and rats. Zebrafish embryos are highly valuable due to their rapid development and manipulability. They...
Transgenic Zebrafish have become an increasingly popular tool for researchers looking to identify human disease-related mutations and the drugs that treat them. This article will focus specifically on fluorescent transgenic Zebrafish lines and how they can be used in drug discovery and development. Advantages of Fluorescent...
/*! elementor - v3.7.3 - 29-08-2022 */ .elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=".svg"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block} Zebrafish cell lines are a valuable tool in the field of drug discovery, with numerous benefits and applications for reproductive drug toxicity screening. Cell lines are groups of cells that can be used repeatedly for...
Model organisms are organisms that are easy to house, develop, and maintain in the laboratory. They are ideal for scientific testing and research because they are adaptable and easy to manipulate. These organisms can be used for all kinds of research, including chemical, disease, and...
Cardiovascular and neurodegenerative diseases are the leading causes of death, morbidity, and disability worldwide. Despite the availability of medical and preventive interventions, damaged tissue regeneration is the only action that can restore proper organ function and reduce patient disability.Tissue regeneration in complex organisms such as...
/*! elementor - v3.7.3 - 29-08-2022 */ .elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=".svg"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block} CLICK’N CUT™ is a universal and robust tool to obtain tag-less proteins in a one-step process based on intein affinity. It is suitable for every step of product and process development: R&D, pre-clinical, clinical and...
