ZIP Solutions’ proprietary SPLITTERA technology is an innovative, universal and robust solution for site-specific conjugation of proteins. It is based on 4 orthogonal split-inteins recognized as the fastest and more specific described so far.
SPLIT-INTEINS are internal protein elements that, upon binding with the complementary split-intein, catalyze the linkage of the two flanking sequences
with a peptide bond and are excised from the precursor proteins. Split-inteins are fragmented in two different genes and are transcribed and translated independently (Figure 1).